Science Advances 10 Feb eabd Open Access The kidney interstitial gene signature is interrogated by laser microdissection, snRNA sequencing, and in situ hybridization. Abstract. Jan 12, · Nearly 50 years after the concept was first proposed, gene therapy is now considered a promising treatment option for several human diseases. The path to success has been long and tortuous. Serious adverse effects were encountered in early clinical studies, but this fueled basic research that led to safer and more efficient gene transfer vectors. Gene therapy .
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In adult subjects with DKA, the overall mortality is 5% has been reported in the elderly and in patients with concomitant life-threatening illnesses (7,8). Death in these conditions is rarely due to the metabolic complications of hyperglycemia or ketoacidosis but relates to the underlying precipitating illness. Oct 26, · Up‐front MSD HSCT for young and adult patients is the treatment of choice for severe AA, but patients aged between 35‐50 years need to be carefully assessed for co‐morbidities prior to consideration for transplantation. Grade 1B; Unrelated donor HSCT in adults should be considered after lack of response to one course of IST. Grade 1B.
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